Book The Best Hotels in Southeast Missouri, MO for 2026 from CA $87 - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A motel with a covered entrance, a flag, and a phone number.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

1. Madison Inn Lodge

Fredericktown

Bawan

CA $123

CA $135 total

includes taxes & fees

Sep 30 - Oct 1

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

2. Fort Davidson Hotel

Ironton

richard

CA $176

CA $193 total

includes taxes & fees

Oct 4 - Oct 5

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

3. Shepherd Mountain Inn

Ironton

Michael

CA $174

CA $190 total

includes taxes & fees

Sep 28 - Sep 29

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

4. Drury Inn & Suites Jackson MO

Jackson

Thomas

CA $121

CA $128 total

includes taxes & fees

Oct 11 - Oct 12

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

5. Super 8 by Wyndham Farmington

Farmington

Marisa

CA $84

CA $91 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

6. Hampton Inn & Suites By Hilton Festus

Festus

Abram

CA $126

CA $145 total

includes taxes & fees

Oct 15 - Oct 16

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

7. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

CA $141

CA $159 total

includes taxes & fees

Oct 1 - Oct 2

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

8. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

CA $124

CA $139 total

includes taxes & fees

Oct 18 - Oct 19

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

9. Crown Pointe Lodge, BW Signature Collection

Farmington

Susan

CA $155

CA $168 total

includes taxes & fees

Oct 2 - Oct 3

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A gym with cardio equipment, a bench press, and a squat rack.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

10. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

ILUNGA

CA $80

CA $87 total

includes taxes & fees

Oct 25 - Oct 26

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A rustic cabin with a wooden exterior, a small deck, and a picnic table.

A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

11. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

Ronrecus

CA $131

CA $213 total

includes taxes & fees

Sep 29 - Sep 30

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A hotel room with two beds, a nightstand, a lamp, and a chair.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

CA $119

CA $128 total

includes taxes & fees

Sep 27 - Sep 28

A modern retail area with a display of local items and snacks.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

13. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

CA $126

CA $144 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a reception desk, seating area, and large windows.

An indoor swimming pool with a clear view of the outside through large windows.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

14. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

CA $134

CA $152 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

15. Super 8 by Wyndham Perryville

Perryville

paulette

CA $101

CA $115 total

includes taxes & fees

Oct 11 - Oct 12

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

16. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

CA $143

CA $161 total

includes taxes & fees

Oct 1 - Oct 2

A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.

A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.

17. Sam A Baker State Park

Patterson

Charlie

CA $190

CA $202 total

includes taxes & fees

Oct 14 - Oct 15

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

18. The Riverview

Cape Girardeau

Alyssa

CA $145

CA $164 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

A swimming pool with a diving board, pool rules signs, and lounge chairs.

19. Holiday Inn Express & Suites Perryville by IHG

Perryville

David

CA $148

CA $170 total

includes taxes & fees

Oct 4 - Oct 5

A red wooden mill with a small bridge over a flowing river, surrounded by lush greenery.

A grassy field with trees in the background.

A playground with a slide, climbing structures, and a small shelter.

A dining area with a round table and chairs, large windows with curtains, and a whiteboard on the wall.

20. Honeysuckle Inn - Mountain View

Mountain View

Joanne

CA $140

CA $151 total

includes taxes & fees

Sep 26 - Sep 27

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Vacation Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Cabin

A calm lake with a wooden dock and a forested island in the distance.

A bedroom with a wooden bed, a bench, and a window.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A red house with a wooden deck and stone steps leading to a porch.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

See all vacation rentals

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Hampton Inn Poplar Bluff

10/10 Excellent

"No problems at all at this property. From the price to the cleanliness, it was all great. Adding it to our travel log to stop at again."

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent

"This hotel was outstanding! The room is huge, clean, and the bed was like heaven! We were on the first floor and has a door leading out of the room into the pool. Was an awesome 4 night stay while we were visiting family. The front desk staff was awesome!"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Una experiencia divina! Todo muy limpio además lleve a my puppy y ellos dejaron platos de comida para perros también! También una correa larga por si es necesario! Lo súper recomiendo"

Drury Inn & Suites Poplar Bluff

10/10 Excellent

"Clean room, staff"

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Easy checkin, clean facilities, safe area. Quiet with a comfy bed."

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"This was a very good value. It has been the best hotel I've stayed at in awhile."

Pear Tree Inn Cape Girardeau West

8/10 Good

"I was looking for something that was good quality and wouldn’t break my wallet. This place was what I was expecting. Lady working the breakfast was extremely polite and helpful."

Silo Farm Haus- located in the heart of wine country!

10/10 Excellent

"We were quite impressed with what has been done with the silo! Everything was clean and comfortable upon our arrival. The area was nice and quiet – just what we were looking for away from the city. Sunsets and star gazing were amazing. We would definitely love to come back to the area in the fall when the leaves have turned."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

CA $80

CA $87 total

Oct 25 - Oct 26

includes taxes & fees

8/10 Very good! (1,003 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $94

CA $107 total

Sep 30 - Oct 1

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $102

CA $115 total

Oct 4 - Oct 5

includes taxes & fees

9.2/10 Wonderful! (1,000 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

CA $104

CA $117 total

Sep 30 - Oct 1

includes taxes & fees

8/10 Very good! (1,000 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

CA $101

CA $118 total

Oct 25 - Oct 26

includes taxes & fees

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

CA $124

CA $139 total

Oct 18 - Oct 19

includes taxes & fees

9.4/10 Exceptional! (951 reviews)

Hotels in Southeast Missouri with star rating

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Book Hotels in Southeast Missouri on Expedia.com

Find hotels in Southeast Missouri, MO from CA $87

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Madison Inn Lodge

2. Fort Davidson Hotel

3. Shepherd Mountain Inn

4. Drury Inn & Suites Jackson MO

5. Super 8 by Wyndham Farmington

6. Hampton Inn & Suites By Hilton Festus

7. Drury Plaza Hotel Cape Girardeau Conference Center

8. Hampton Inn Poplar Bluff

9. Crown Pointe Lodge, BW Signature Collection

10. Baymont Inn and Suites by Wyndham Farmington, MO

11. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

13. Tru By Hilton Cape Girardeau

14. Drury Inn & Suites Poplar Bluff

15. Super 8 by Wyndham Perryville

16. Fairfield Inn & Suites by Marriott Cape Girardeau

17. Sam A Baker State Park

18. The Riverview

19. Holiday Inn Express & Suites Perryville by IHG

20. Honeysuckle Inn - Mountain View

Vacation Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Lake Wappapello

The Atrium - A Boutique Hotel

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Urban Lofts

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Hampton Inn Poplar Bluff

Baymont Inn and Suites by Wyndham Farmington, MO

Drury Inn & Suites Sikeston, MO

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Drury Inn & Suites Poplar Bluff

Motel 6 Poplar Bluff, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Silo Farm Haus- located in the heart of wine country!

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Motel 6 Poplar Bluff, MO

Comfort Inn Festus - St Louis South

Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star rating

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