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Our top choices for Southeast Missouri hotels

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

1. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

CA $88 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

2. Hampton Inn & Suites By Hilton Festus

Festus

Misty

CA $180 total

includes taxes & fees

Nov 15 - Nov 16

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

3. Super 8 by Wyndham Farmington

Farmington

Marisa

CA $96 total

includes taxes & fees

Nov 15 - Nov 16

A motel with a covered entrance, a flag, and a phone number.

4. Madison Inn Lodge

Fredericktown

Bawan

CA $131 total

includes taxes & fees

Nov 10 - Nov 11

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

5. Hampton Inn Farmington

Farmington

Charlie

CA $166 total

includes taxes & fees

Nov 20 - Nov 21

A bathroom with a white sink, a mirror, a towel rack, a toilet, and a shower curtain.

6. Shepherd Mountain Inn

Ironton

Jonathan

CA $190 total

includes taxes & fees

Nov 10 - Nov 11

A spacious lobby with a reception desk, seating area, and large windows.

7. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

CA $144 total

includes taxes & fees

Nov 15 - Nov 16

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

8. Holiday Inn Express & Suites Farmington by IHG

Farmington

January

CA $186 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

9. Fort Davidson Hotel

Ironton

richard

CA $185 total

includes taxes & fees

Nov 17 - Nov 18

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

10. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Melody

CA $159 total

includes taxes & fees

Nov 14 - Nov 15

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

11. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

richard

CA $122 total

includes taxes & fees

Nov 12 - Nov 13

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

12. Crown Pointe Lodge, BW Signature Collection

Farmington

christopher

CA $163 total

includes taxes & fees

Nov 19 - Nov 20

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

13. Super 8 By Wyndham Marston

Marston

Wendy

CA $93 total

includes taxes & fees

Nov 11 - Nov 12

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

14. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

CA $155 total

includes taxes & fees

Nov 15 - Nov 16

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

15. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

CA $141 total

includes taxes & fees

Dec 6 - Dec 7

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

16. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Dane

CA $161 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

17. Drury Inn & Suites Jackson MO

Jackson

Leonardo

CA $119 total

includes taxes & fees

Nov 22 - Nov 23

A hotel lobby with a reception desk, seating area, and a patterned carpet.

18. Holiday Inn Express & Suites Perryville by IHG

Perryville

allan p.

CA $163 total

includes taxes & fees

Nov 15 - Nov 16

A spacious cafe with wooden tables and chairs, large windows, and a bar area.

19. Holiday Inn Poplar Bluff by IHG

Poplar Bluff

Nathan

CA $128 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

20. Super 8 by Wyndham Perryville

Perryville

Matthew

CA $111 total

includes taxes & fees

Dec 1 - Dec 2

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Vacation Rentals in Southeast Missouri

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A wooden deck with a hot tub, a small table, and a bench.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

Cottage

A log cabin with a glass door leading to an outdoor patio, a grill, and a table with chairs.

Peaceful 2-cabin Property: 1 Mi to Current River!

Van Buren

"We had the best time. We had plenty of room for our families that were in town for a wedding. The rental had everything we needed."

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

8/10 Good

"The room was clean and fresh. But I couldn’t say that about the breakfast area. The food was cold, no coffee, the juice machine was gross, the floor was wet and sticky. Kept running out of food. The trash area stunk around the food. Also the elevator floors were always wet and sticky as well."

Silo Farm Haus- located in the heart of wine country!

10/10 Excellent

"Visited for the weekend with my wife to celebrate our anniversary. The Silo Farm Haus was absolutely perfect! The views of the rolling farmland were gorgeous. Inside was cozy and beautifully decorated. We had a wonderful time and would highly recommend staying here if you get the chance."

Lake Wappapello

10/10 Excellent

"This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from the park. We ordered deli sandwiches from here and picked up some icecream. The sandwiches were delicious and the store had pretty much whatever you might need. The checkin process was great with good communication about which cabin to go to, what the door code was etc... We plan to come back for a longer stay so we can have another evening around the firepit and see all of the stars. Great place to stay."