Find hotels in Southeast Missouri, MO from CA $85
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Check prices for these dates
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Aug 10 - Aug 11Tomorrow
Aug 11 - Aug 12This weekend
Aug 14 - Aug 16Next weekend
Aug 21 - Aug 23Our top choices for Southeast Missouri hotels
1. Madison Inn Lodge
Madison Inn LodgeFredericktown
Christine
CA $122
CA $133 total
includes taxes & fees
Aug 21 - Aug 22
2. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
Jamie
CA $113
CA $119 total
includes taxes & fees
Aug 16 - Aug 17
3. Shepherd Mountain Inn
Shepherd Mountain InnIronton
Katie
CA $172
CA $188 total
includes taxes & fees
Sep 7 - Sep 8
4. Fort Davidson Hotel
Fort Davidson HotelIronton
John
CA $174
CA $190 total
includes taxes & fees
Aug 24 - Aug 25
5. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
Louise
CA $153
CA $166 total
includes taxes & fees
Sep 6 - Sep 7
6. Super 8 by Wyndham Farmington
Super 8 by Wyndham FarmingtonFarmington
Sarah
CA $83
CA $90 total
includes taxes & fees
Aug 20 - Aug 21
7. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
Kellie
CA $78
CA $85 total
includes taxes & fees
Sep 6 - Sep 7
8. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
JANEEN
CA $108
CA $117 total
includes taxes & fees
Aug 14 - Aug 15
9. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Paul
CA $139
CA $157 total
includes taxes & fees
Aug 24 - Aug 25
10. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
Heather
CA $118
CA $133 total
includes taxes & fees
Aug 19 - Aug 20
11. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Philip
CA $136
CA $152 total
includes taxes & fees
Sep 10 - Sep 11
12. Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
Elaine
CA $131
CA $148 total
includes taxes & fees
Aug 24 - Aug 25
13. Holiday Inn Express & Suites Farmington by IHG
Holiday Inn Express & Suites Farmington by IHGFarmington
Tara
CA $146
CA $159 total
includes taxes & fees
Aug 23 - Aug 24
14. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
Jean
CA $141
CA $159 total
includes taxes & fees
Aug 23 - Aug 24
15. Perryville RV Resort
Perryville RV ResortPerryville
Von
CA $93
CA $106 total
includes taxes & fees
Aug 12 - Aug 13
16. Black River Motel and Restaurant
Black River Motel and RestaurantLesterville
Douglas
CA $162
CA $171 total
includes taxes & fees
Aug 12 - Aug 13
17. The Riverview
The RiverviewCape Girardeau
James
CA $147
CA $165 total
includes taxes & fees
Aug 16 - Aug 17
18. Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
Gwendolyn
CA $125
CA $142 total
includes taxes & fees
Sep 3 - Sep 4
19. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
Jkara
CA $129
CA $140 total
includes taxes & fees
Aug 13 - Aug 14
20. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Dwain
CA $153
CA $174 total
includes taxes & fees
Aug 23 - Aug 24
Vacation Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Vacation Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"I was a great experience loved everything about it"
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Cottage
40-acre Poplar Bluff Nature Lovers Paradise!
40-acre Poplar Bluff Nature Lovers Paradise!Poplar Bluff
"Beautiful place enjoyed our stay"
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
Cottage
Cottage w/ Yard, Walk to Historic Attractions
Cottage w/ Yard, Walk to Historic AttractionsSte Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Photo by JG Morris
Lake Wappapello
8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Baymont by Wyndham Festus
8/10 Good
"Breakfast above average. Curtain did no shut off all outside light. Floor in bathroom needs to cleaned not just wet mopped over and done. I spilled some water and wiped it up and came back black and with some hair which indicates it was not cleaned properly. Wonder about regular floor. No instructions on TV channels and what was free. Ice machine on 1st floor out back door works great but is rusting out at legs. Hope they clean the ice dispensing shout I would stay there again."
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"Great stay!"
Drury Inn & Suites Poplar Bluff
10/10 Excellent
"Excellent free dinner and hot breakfast. Indoor and outdoor pool. Terrific staff."
Candlewood Suites Cape Girardeau by IHG
10/10 Excellent
"Our stove had a short in it so I wasn’t able to cook"
Motel 6 Poplar Bluff, MO
8/10 Good
"Nice hotel and priced right! Very convenient and easy to find!"
Honeysuckle Inn - Mountain View
10/10 Excellent
"Nice clean little hotel! Great price too"
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"Everything about this property is 1000000/100000"
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"Very nice hotel and staff. Would definitely recommend "
The Farmstead Hotel
10/10 Excellent
"Very nice room for the price. Everything was clean and in order upon our arrival. Prompt service when requesting extra towels. Employees that we encountered were friendly and helpful."
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
CA $78
CA $85 total
Sep 6 - Sep 7
includes taxes & fees
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
CA $84
CA $99 total
Sep 6 - Sep 7
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
CA $90
CA $103 total
Sep 10 - Sep 11
includes taxes & fees
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
CA $100
CA $112 total
Aug 16 - Aug 17
includes taxes & fees
8/10 Very good! (1,013 reviews)
The Farmstead Hotel
778 E 3rd St Caruthersville MO
CA $101
CA $115 total
Aug 23 - Aug 24
includes taxes & fees
8.6/10 Excellent! (591 reviews)
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
CA $146
CA $165 total
Sep 3 - Sep 4
includes taxes & fees
9.4/10 Exceptional! (1,008 reviews)
Hotels in Southeast Missouri with star rating
4 Star Hotels
2 properties
3 Star Hotels
68 properties
2 Star Hotels
90 properties
Explore a world of travel with Expedia
- Crown Pointe Lodge
- Cabin Rentals in Centerville
- The Queen Bee Farm Stay/Hot tub
- Park Hills Hotels
- Hotels near Big River
- Cabin Rentals in Allenville
- French Village Hotels
- Dexter Inn
- Poplar Bluff Hotels
- Pine Perfect Cabin on the edge of town only 1/2 mile from Current River!
- Bonne Terre Hotels
- Cabin Rentals in Farmington
- Holiday Inn Poplar Bluff by IHG
- Resorts in Wayne County
- Secluded Cabin with Heated Pool
- Amazing lakeview Spring Lake Tree House #2 "LoveLight" w/ hot tub
- Pickleball Cafe & Micro Hotel
- Urban Loft #4 BLACK · Urban Loft above BrewCo & Restaurant
- Motels in Ellsinore
- Fredericktown Hotels
- Morehouse Hotels
- Rv Parks in Perryville
- Advance Hotels
- Quality Inn Perryville I
- Lazy River Cabin on the edge of town only 1/2 mile from Current River !
- Doniphan Hotels
- Bluebird Meadows W/hot Tub and Pool Special
- Silo Farm Haus
- Dexter Hotels
- B&B in Ste Genevieve
- Bullwinkles Rustic Lodge
- Pet-Friendly Hotels in Jackson
- Postcard Cabins St Francois
- Villas in Poplar Bluff
- Cheap Hotels in Viburnum
- Cottages in Pocahontas
- Cabin Rentals in Bonne Terre
- Oyo Hickory House Inn
- Condo Rentals in Fremont
- Scott City Hotels
- Rv Parks in Chaffee
- Hilton Hotels in Perryville
- Relax in the country at Countryside Villas!
- Apartments in Ozora
- Secluded Private Cabin with Pool
- Home Sweet Home
- Van Buren Hotels
- Farmstay in Oak Ridge
- Cozy Caledonia Cabin ~ 10 Mi to Elephant Rocks!
- Cabin Rentals in Southeast Missouri
- Cottages in Clearwater
- Cabin Rentals in Cadet
- Houseboats in Wappapello
- Spring Lake Ranch has a Private
- Alpaca Farm Stay
- Jackson Hotels
- Super 8 by Wyndham Perryville
- Motels in St Mary
- Winona Hotels
- Hilton Hotels in Ste Genevieve
- Triangle Inn Motel
- Hampton Inn Poplar Bluff
- Cheap Hotels in Bonne Terre
- Cabin Rentals in Leadwood
- Town House Inn
- Ozora Hotels
- Essex Hotels
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